Table of Contents Author Guidelines Submit a Manuscript
Oxidative Medicine and Cellular Longevity
Volume 2017, Article ID 4708516, 16 pages
https://doi.org/10.1155/2017/4708516
Research Article

miR-382 Contributes to Renal Tubulointerstitial Fibrosis by Downregulating HSPD1

1Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China
2Shanghai Institute of Kidney and Dialysis, Shanghai, China
3Shanghai Key Laboratory of Kidney and Blood Purification, Shanghai, China
4Department of Hematology, Zhongshan Hospital, Fudan University, Shanghai, China
5Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA

Correspondence should be addressed to Mingyu Liang; ude.wcm@gnailm and Xiaoqiang Ding; nc.hs.latipsoh-sz@gnaiqoaix.gnid

Received 2 February 2017; Revised 30 March 2017; Accepted 5 April 2017; Published 7 June 2017

Academic Editor: Jaideep Banerjee

Copyright © 2017 Yi Fang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. J. Stahl and D. Felsen, “Transforming growth factor-β, basement membrane, and epithelial-mesenchymal transdifferentiation: implications for fibrosis in kidney disease,” The American Journal of Pathology, vol. 159, no. 4, pp. 1187–1192, 2001. View at Publisher · View at Google Scholar
  2. M. Iwano and E. G. Neilson, “Mechanisms of tubulointerstitial fibrosis,” Current Opinion in Nephrology and Hypertension, vol. 13, no. 3, pp. 279–284, 2004. View at Publisher · View at Google Scholar · View at Scopus
  3. M. Iwano, D. Plieth, T. M. Danoff, C. Xue, H. Okada, and E. G. Neilson, “Evidence that fibroblasts derive from epithelium during tissue fibrosis,” The Journal of Clinical Investigation, vol. 110, no. 3, pp. 341–350, 2002. View at Publisher · View at Google Scholar
  4. T. D. Hewitson, “Renal tubulointerstitial fibrosis: common but never simple,” American Journal of Physiology. Renal Physiology, vol. 296, no. 6, pp. F1239–F1244, 2009. View at Google Scholar
  5. A. J. Kriegel, Y. Fang, Y. Liu et al., “MicroRNA-target pairs in human renal epithelial cells treated with transforming growth factor β1: a novel role of miR-382,” Nucleic Acids Research, vol. 38, no. 22, pp. 8338–8347, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. D. S. Reading, R. L. Hallberg, and A. M. Myers, “Characterization of the yeast HSP60 gene coding for a mitochondrial assembly factor,” Nature, vol. 337, no. 6208, pp. 655–659, 1989. View at Publisher · View at Google Scholar
  7. H. Tang, E. Tian, C. Liu, Q. Wang, and H. Deng, “Oxidative stress induces monocyte necrosis with enrichment of cell-bound albumin and overexpression of endoplasmic reticulum and mitochondrial chaperones,” PloS One, vol. 8, no. 3, article e59610, 2013. View at Publisher · View at Google Scholar · View at Scopus
  8. E. Cabiscol, G. Belli, J. Tamarit, P. Echave, E. Herrero, and J. Ros, “Mitochondrial Hsp60, resistance to oxidative stress, and the labile iron pool are closely connected in Saccharomyces cerevisiae,” The Journal of Biological Chemistry, vol. 277, no. 46, pp. 44531–44538, 2002. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Y. Cheng, F. U. Hartl, J. Martin et al., “Mitochondrial heat-shock protein hsp60 is essential for assembly of proteins imported into yeast mitochondria,” Nature, vol. 337, no. 6208, pp. 620–625, 1989. View at Publisher · View at Google Scholar
  10. K. P. Poulianiti, A. Kaltsatou, G. I. Mitrou et al., “Redox imbalance in chronic kidney disease: a systematic review,” Oxidative Medicine and Cellular Longevity, vol. 2016, Article ID 8598253, 19 pages, 2006. View at Publisher · View at Google Scholar · View at Scopus
  11. H. Terawaki, K. Yoshimura, T. Hasegawa et al., “Oxidative stress is enhanced in correlation with renal dysfunction: examination with the redox state of albumin,” Kidney International, vol. 66, no. 5, pp. 1988–1993, 2004. View at Publisher · View at Google Scholar
  12. C. Maric, K. Sandberg, and C. Hinojosa-Laborde, “Glomerulosclerosis and tubulointerstitial fibrosis are attenuated with 17β-estradiol in the aging Dahl salt sensitive rat,” Journal of the American Society of Nephrology, vol. 15, no. 6, pp. 1546–1556, 2004. View at Publisher · View at Google Scholar · View at Scopus
  13. Y. Fang, X. Yu, Y. Liu et al., “MiR-29c is down-regulated in renal interstitial fibrosis in humans and rats and restored by HIF- activation,” American Journal of Physiology. Renal Physiology, vol. 304, no. 10, pp. F1274–F1282, 2013. View at Publisher · View at Google Scholar · View at Scopus
  14. L. Tongqiang, L. Shaopeng, Y. Xiaofang et al., “Salvianolic acid B prevents iodinated contrast media-induced acute renal injury in rats via the PI3K/AKT/Nrf2 pathway,” Oxidative Medicine and Cellular Longevity, vol. 2016, Article ID 7079487, 11 pages, 2016. View at Publisher · View at Google Scholar · View at Scopus
  15. A. A. Eddy, “Molecular insights into renal interstitial fibrosis,” Journal of the American Society of Nephrology, vol. 7, no. 12, pp. 2495–2508, 1996. View at Google Scholar
  16. E. Healy and H. R. Brady, “Role of tubule epithelial cells in the pathogenesis of tubulointerstitial fibrosis induced by glomerular disease,” Current Opinion in Nephrology and Hypertension, vol. 7, no. 5, pp. 525–530, 1998. View at Publisher · View at Google Scholar · View at Scopus
  17. A. Bohle, H. Christ, K. E. Grund, and S. Mackensen, “The role of the interstitium of the renal cortex in renal disease,” Contributions to Nephrology, vol. 16, pp. 109–114, 1979. View at Google Scholar
  18. G. Greenburg and E. D. Hay, “Epithelia suspended in collagen gels can lose polarity and express characteristics of migrating mesenchymal cells,” The Journal of Cell Biology, vol. 95, no. 1, pp. 333–339, 1982. View at Publisher · View at Google Scholar
  19. W. Kriz, B. Kaissling, and M. Le Hir, “Epithelial-mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy?” The Journal of Clinical Investigation, vol. 121, no. 2, pp. 468–474, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. M. Zeisberg and J. S. Duffield, “Resolved: EMT produces fibroblasts in the kidney,” Journal of the American Society of Nephrology, vol. 21, no. 8, pp. 1247–1253, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. R. Kalluri, “EMT: when epithelial cells decide to become mesenchymal-like cells,” The Journal of Clinical Investigation, vol. 119, no. 6, pp. 1417–1419, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Zeisberg and E. G. Neilson, “Mechanisms of tubulointerstitial fibrosis,” Journal of the American Society of Nephrology, vol. 21, no. 11, pp. 1819–1834, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. X. Yu, Y. Fang, X. Ding et al., “Transient hypoxia-inducible factor activation in rat renal ablation and reduced fibrosis with L-mimosine,” Nephrology (Carlton, Vic.), vol. 17, no. 1, pp. 58–67, 2012. View at Publisher · View at Google Scholar · View at Scopus
  24. M. Liang, Y. Liu, D. Mladinov et al., “MicroRNA: a new frontier in kidney and blood pressure research,” American Journal of Physiology. Renal Physiology, vol. 297, no. 3, pp. F553–F558, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. J. Winter, S. Jung, S. Keller, R. I. Gregory, and S. Diederichs, “Many roads to maturity: microRNA biogenesis pathways and their regulation,” Nature Cell Biology, vol. 11, no. 3, pp. 228–234, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. J. Krol, I. Loedige, and W. Filipowicz, “The widespread regulation of microRNA biogenesis, function and decay,” Nature Reviews. Genetics, vol. 11, no. 9, pp. 597–610, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. M. Xu, H. Jin, C. X. Xu et al., “miR-382 inhibits osteosarcoma metastasis and relapse by targeting Y box-binding protein 1,” Molecular Therapy, vol. 23, no. 1, pp. 89–98, 2015. View at Publisher · View at Google Scholar · View at Scopus
  28. G. Meister, “miRNAs get an early start on translational silencing,” Cell, vol. 131, no. 1, pp. 25–28, 2007. View at Publisher · View at Google Scholar · View at Scopus
  29. L. P. Lim, N. C. Lau, A. Grimson et al., “Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs,” Nature, vol. 433, no. 7027, pp. 769–773, 2005. View at Publisher · View at Google Scholar · View at Scopus
  30. A. J. Kriegel, Y. Liu, B. Cohen, Y. Liu, and M. Liang, “MiR-382 targeting of kallikrein 5 contributes to renal inner medullary interstitial fibrosis,” Physiological Genomics, vol. 44, no. 4, pp. 259–267, 2012. View at Publisher · View at Google Scholar · View at Scopus
  31. R. Sengupta and A. Holmgren, “Thioredoxin and glutaredoxin-mediated redox regulation of ribonucleotide reductase,” World Journal of Biological Chemistry, vol. 5, no. 1, pp. 68–74, 2014. View at Publisher · View at Google Scholar
  32. E. M. Hanschmann, J. R. Godoy, C. Berndt, C. Hudemann, and C. H. Lillig, “Thioredoxins, glutaredoxins, and peroxiredoxins-molecular mechanisms and health significance: from cofactors to antioxidants to redox signaling,” Antioxidants & Redox Signaling, vol. 19, no. 13, pp. 1539–1605, 2013. View at Publisher · View at Google Scholar · View at Scopus
  33. J. Lu and A. Holmgren, “The thioredoxin antioxidant system,” Free Radical Biology & Medicine, vol. 66, pp. 75–87, 2014. View at Publisher · View at Google Scholar · View at Scopus
  34. F. Yamakura, H. Taka, T. Fujimura, and K. Murayama, “Inactivation of human manganese-superoxide dismutase by peroxynitrite is caused by exclusive nitration of tyrosine 34 to 3-nitrotyrosine,” The Journal of Biological Chemistry, vol. 273, no. 23, pp. 14085–14089, 1998. View at Publisher · View at Google Scholar · View at Scopus
  35. M. F. Beal, R. J. Ferrante, S. E. Browne, R. T. Matthews, N. W. Kowall, and R. H. Brown Jr., “Increased 3-nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis,” Annals of Neurology, vol. 42, no. 4, pp. 644–654, 1997. View at Publisher · View at Google Scholar · View at Scopus
  36. A. Ceriello, F. Mercuri, L. Quagliaro et al., “Detection of nitrotyrosine in the diabetic plasma: evidence of oxidative stress,” Diabetologia, vol. 44, no. 7, pp. 834–838, 2001. View at Publisher · View at Google Scholar · View at Scopus