Oxidative Medicine and Cellular Longevity / 2017 / Article / Fig 5

Research Article

Blockage of NOX2/MAPK/NF-κB Pathway Protects Photoreceptors against Glucose Deprivation-Induced Cell Death

Figure 5

Inhibition of NOX2 suppresses caspase-dependent apoptotic pathway. (a) 661W cells were cultured in normal, glucose-free medium, or in the presence of 100 μM NSC or APO for indicated time periods. Cell lysates were collected and subjected to Western blot analysis of gp91, cleaved caspase-3, Bax, and Bcl-2. Actin protein was used as a loading control. (b) Protein bands on the Western blots were scanned, and the intensity was determined by optical density measurements. The results are presented as means ± SEM (, compared to the control group, ### compared to the vehicle group; one-way ANOVA and Bonferroni test).

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