Blockage of NOX2/MAPK/NF-κB Pathway Protects Photoreceptors against Glucose Deprivation-Induced Cell Death
Inhibition of NOX2 suppresses caspase-dependent apoptotic pathway. (a) 661W cells were cultured in normal, glucose-free medium, or in the presence of 100 μM NSC or APO for indicated time periods. Cell lysates were collected and subjected to Western blot analysis of gp91, cleaved caspase-3, Bax, and Bcl-2. Actin protein was used as a loading control. (b) Protein bands on the Western blots were scanned, and the intensity was determined by optical density measurements. The results are presented as means ± SEM (, compared to the control group, ### compared to the vehicle group; one-way ANOVA and Bonferroni test).
We are committed to sharing findings related to COVID-19 as quickly and safely as possible. Any author submitting a COVID-19 paper should notify us at email@example.com to ensure their research is fast-tracked and made available on a preprint server as soon as possible. We will be providing unlimited waivers of publication charges for accepted articles related to COVID-19. Sign up here as a reviewer to help fast-track new submissions.