Tubulin Beta-3 Chain as a New Candidate Protein Biomarker of Human Skin Aging: A Preliminary Study
Table 4
List of top enriched pathways provided after overrepresentation analysis with PathVisio. Positive (r) is the number of genes in the pathway meeting the criterion. Measured (n) is the number of genes in the pathway measured in the experiment. Total is the total number of elements in the pathway. Z-score is the score calculated for overrepresentation analysis. Pathways with a high Z-score have more significantly up- or downregulated genes than expected.
Pathway
Positive (r)
Measured (n)
Total
%
Z-score
value (permuted)
Zinc homeostasis
4
4
39
100.00%
3.30
0.000
Copper homeostasis
5
6
58
83.33%
3.13
0.000
Arachidonate epoxygenase/epoxide hydrolase
2
2
17
100.00%
2.33
0.001
DNA replication
2
2
50
100.00%
2.33
0.009
Retinoblastoma (RB) in cancer
2
2
98
100.00%
2.33
0.012
Histone modifications
11
25
69
44.00%
1.98
0.027
Aryl hydrocarbon receptor
1
1
51
100.00%
1.65
0.048
Cardiac hypertrophic response
1
1
60
100.00%
1.65
0.063
Constitutive androstane receptor pathway
1
1
34
100.00%
1.65
0.029
Dual hijack model of Vif in HIV infection
1
1
9
100.00%
1.65
0.007
Endochondral ossification
1
1
69
100.00%
1.65
0.072
Endothelin pathways
1
1
47
100.00%
1.65
0.047
Gastric cancer network 1
1
1
32
100.00%
1.65
0.027
Melatonin metabolism and effects
1
1
55
100.00%
1.65
0.057
NOTCH1 regulation of human endothelial cell calcification
