Rhinacanthin C Alleviates Amyloid-β Fibrils’ Toxicity on Neurons and Attenuates Neuroinflammation Triggered by LPS, Amyloid-β, and Interferon-γ in Glial Cells

Figure 5

RC inhibits IL-6 and TNF-α secretion in LPS-activated microglia. BV-2 cells were treated with LPS (100 ng/mL) for 24 h following 1 h exposure to RC (0.625–0.5 μM). Cell supernatants were collected for IL-6 (a) and TNF-α (b) detection by ELISA. Data are represented as mean ± SEM (). The significance of the data were analyzed by one-way ANOVA with post hoc Dunnett’s test. ^### versus control; versus LPS. (c) Cell viability was assessed by the MTT assay. Statistical analysis was performed by Student’s t-test. versus LPS.

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