Kiwifruit Alleviates Learning and Memory Deficits Induced by Pb through Antioxidation and Inhibition of Microglia Activation In Vitro and In Vivo

Figure 10

Graphical abstract. In response to oxidative stress induced by Pb, microglia become activated and released cytotoxic factors such as TNF-α and IL-1β, leading to serious neurotoxic effects including cognition deficit and the dendritic spine loss, while with the supplement of kiwifruit it reduced the oxidative stress and inhibited the microglia activation, manifested as the improved learning and memory ability. Kiwifruit can be a potential complementary diet agent in the prevention and treatment of lead intoxication.