Research Article
Modulation of Multidrug Resistance Gene Expression by Coumarin Derivatives in Human Leukemic Cells
Table 2
IC10 + M values for line cells CEM/C1, CCRF/CEM, HL-60, HL-60/MX1, and HL-60/MX2 (μM). SD: standard deviation.
| | CEM/C1 | CCRF/CEM | HL-60 | HL-60/MX1 | HL-60/MX2 | | IC10 ± SD | IC10 ± SD | IC10 ± SD | IC10 ± SD | IC10 ± SD |
| | ISO | 12.8 ± 2.5 | 8.0 ± 0.5 | 5.6 ± 0.5 | 14.0 ± 1.5 | 16.8 ± 2.5 | | BER | 12.3 ± 2.0 | 7.7 ± 1.0 | 5.2 ± 0.4 | 13.4 ± 1.8 | 12.7 ± 2.0 | | XOL | 13.0 ± 2.1 | 9.1 ± 1.1 | 5.6 ± 0.6 | 10.3 13.1 | 10.7 ± 1.4 | | XIN | 14.7 ± 2.1 | 10.2 ± 2.1 | 9.4 ± 1.1 | 12.0 ± 2.1 | 10.2 ± 1.3 | | BIN | 15.0 ± 2.6 | 8.2 ± 1.6 | 6.6 ± 0.6 | 11.8 ± 2.6 | 11.1 ± 2.6 | | BOL | 12.0 ± 2.5 | 7.1 ± 0.8 | 14.7 ± 2.5 | 13.0 ± 2.5 | 11.0 ± 2.5 | | HEC | 14.3 ± 2.5 | 6.6 ± 2.1 | 10.2 ± 2.5 | 14.0 ± 2.5 | 15.9 ± 2.5 | | FEL | 17.3 ± 3.5 | 6.4 ± 2.6 | 11.0 ± 3.5 | 12.2 ± 3.5 | 15.7 ± 3.5 | | HER | 4.2 ± 0.6 | 5.1 ± 0.5 | 4.2 ± 0.4 | 17.3 ± 2.5 | 6.4 ± 0.5 | | AET | 5.3 ± 0.5 | 4.3 ± 1.0 | 10.0 ± 2.0 | 10.2 ± 2.0 | 6.2 ± 1.0 | | DHD | 5.1 ± 0.6 | 5.6 ± 1.1 | 5.8 ± 0.7 | 3.8 ± 0.5 | 6.2 ± 1.1 | | COU | 5.0 ± 0.4 | 1.2 ± 0.1 | 6.2 ± 0.5 | 4.2 ± 0.5 | 4.8 ± 0.6 | | AEL | 4.8 ± 0.6 | 4.0 ± 0.6 | 6.4 ± 2.6 | 2.3 ± 2.6 | 7.6 ± 2.6 | | UMB | 5.2 ± 0.5 | 4.2 ± 0.5 | 6.8 ± 2.5 | 13.0 ± 2.5 | 7.8 ± 1.5 | | 4,7M | 3.2 ± 0.5 | 6.3 0.7 | 4.1 ± 2.5 | 14.8 ± 2.5 | 6.2 ± 0.5 | | 4,7E | 1.7 ± 0.2 | 5.2 ± 0.5 | 2.3 ± 3.5 | 14.8 ± 3.5 | 7.2 ± 1.5 | | 7ME | 4.1 ± 0.5 | 4.2 ± 0.5 | 8.2 ± 2.5 | 13.8 ± 2.5 | 7.6 ± 1.5 | | 6ME | 3.2 ± 0.8 | 6.2 ± 1.0 | 6.8 ± 2.0 | 16.2 ± 2.0 | 4.8 ± 2.0 | | 0,0D | 2.2 ± 0.6 | 4.8 ± 1.1 | 4.0 ± 0.5 | 10.4 ± 2.1 | 7.4 ± 1.1 | | SCO | 2.4 ± 0.2 | 6.8 ± 2.1 | 4.2 ± 2.1 | 20.2 ± 2.1 | 6.4 ± 2.1 |
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