Differential Regulation of Cardiac Function and Intracardiac Cytokines by Rapamycin in Healthy and Diabetic Rats

Figure 4

Changes in cardiac cytokines of ZO-Control rats compared to ZL-Control rats. Significant differential expression of 20 cytokines was determined in cardiac tissues of ZO-C and ZL-C rats. The heatmap is a graphic representation of relative expression of cardiac protein levels with individual cardiac samples arranged along the -axis and protein markers along the -axis. Expression was normalized for each protein across all animals (across each row). Average relative expression in ZO-C hearts compared to ZL-C hearts for each respective protein is given as a percentage next to each row. Statistical significance was determined using Student’s t-test. for all proteins, for each group.