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Oxidative Medicine and Cellular Longevity
Volume 2017, Article ID 5762172, 18 pages
Review Article

Antidepressant Flavonoids and Their Relationship with Oxidative Stress

1Department of Biology, Alexandru Ioan Cuza University of Iasi, Bd. Carol I No. 11, 700506 Iasi, Romania
2Department of Pharmaceutical Chemistry, M. M. College of Pharmacy, Mullana, Maharishi Markandeshwar University, Ambala, Haryana 133203, India
3Department of Molecular Biology and Genetics, Erzurum Technical University, 25000 Erzurum, Turkey
4Departamento de Farmácia, Universidade Federal de Sergipe, 49100-000 São Cristóvão, SE, Brazil
5Departamento de Ciências Farmacêuticas, Universidade Federal da Paraíba, 58051-970 João Pessoa, PB, Brazil

Correspondence should be addressed to Damião Pergentino de Sousa; rb.moc.oohay@asuosed_oaimad

Received 7 September 2017; Accepted 22 November 2017; Published 19 December 2017

Academic Editor: Kota V. Ramana

Copyright © 2017 Lucian Hritcu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Depression is a serious disorder that affects hundreds of millions of people around the world and causes poor quality of life, problem behaviors, and limitations in activities of daily living. Therefore, the search for new therapeutic options is of high interest and growth. Research on the relationship between depression and oxidative stress has shown important biochemical aspects in the development of this disease. Flavonoids are a class of natural products that exhibit several pharmacological properties, including antidepressant-like activity, and affects various physiological and biochemical functions in the body. Studies show the clinical potential of antioxidant flavonoids in treating depressive disorders and strongly suggest that these natural products are interesting prototype compounds in the study of new antidepressant drugs. So, this review will summarize the chemical and pharmacological perspectives related to the discovery of flavonoids with antidepressant activity. The mechanisms of action of these compounds are also discussed, including their actions on oxidative stress relating to depression.