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Oxidative Medicine and Cellular Longevity
Volume 2017 (2017), Article ID 5812401, 18 pages
Review Article

Effects of Polyphenol Intake on Metabolic Syndrome: Current Evidences from Human Trials

1Cardiovascular Science Institute (ICCC)-Biomedical Research Institute Sant Pau (IIB-Sant Pau), Hospital de la Santa Creu I Sant Pau, Barcelona, Spain
2CiberCV, Institute Carlos III, Barcelona, Spain

Correspondence should be addressed to Gemma Chiva-Blanch

Received 17 April 2017; Revised 3 July 2017; Accepted 13 July 2017; Published 15 August 2017

Academic Editor: Ryuichi Morishita

Copyright © 2017 Gemma Chiva-Blanch and Lina Badimon. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Metabolic syndrome (MetS) is a cluster of cardiovascular risk factors which severely increases the risk of type II diabetes and cardiovascular disease. Several epidemiological studies have observed a negative association between polyphenol intake and MetS rates. Nevertheless, there are relatively small numbers of interventional studies evidencing this association. This review is focused on human interventional trials with polyphenols as polyphenol-rich foods and dietary patterns rich in polyphenols in patients with MetS. Current evidence suggests that polyphenol intake has the potential to alleviate MetS components by decreasing body weight, blood pressure, and blood glucose and by improving lipid metabolism. Therefore, high intake of polyphenol-rich foods such as nuts, fruits, vegetables, seasoning with aromatic plants, spices, and virgin olive oil may be the cornerstone of a healthy diet preventing the development and progression of MetS, although there is no polyphenol or polyphenol-rich food able to influence all MetS features. However, inconsistent results have been found in different trials, and more long-term randomized trials are warranted to develop public health strategies to decrease MetS rates.