Metallothionein in Brain Disorders

Figure 2

Schematic representation of MT-I and MT–II gen. The cis-acting response elements: glucocorticoids responsive elements (GREs), metal responsive elements (MREs), and antioxidant responsive elements (AREs). Signal transducter and activator of transcription (STAT) Sp1-binding site (Sp1), upstream stimulatory factor (USF), and metalloregulatory transcription factor with functional domains (MTF-1).