Baicalin Ameliorates Experimental Liver Cholestasis in Mice by Modulation of Oxidative Stress, Inflammation, and NRF2 Transcription Factor

Figure 4

Baicalin significantly reduced BDL-induced oxidative/nitrative stress in mouse liver. BDL caused significant increase in oxidative and nitrative stress as measured by HNE protein adducts and protein nitration using commercial ELISA kits. BDL induced nitrative stress and oxidative stresses (a) and was attenuated by baicalin treatment. Results are mean ± S.E.M. for each group. versus control and ^# versus BDL. Real-time PCR analyses were performed for NOX2 and iNOS genes (b). BDL induced both gene expression, and the inductions were significantly reduced by baicalin treatment. Results are mean ± S.E.M. for each group. versus control and ^# versus BDL.

(a)

(b)