Baicalin Ameliorates Experimental Liver Cholestasis in Mice by Modulation of Oxidative Stress, Inflammation, and NRF2 Transcription Factor

Figure 8

Baicalin attenuated profibrotic gene expression in isolated mouse stellate cells. Stellates were cultured for 8 days to stimulate activation in culture and compared with fresh isolated stellate cells (day 0). Real-time PCR analyses of profibrotic mRNA of smooth muscle actin alpha (SMA), TIMP1, collagen 1, and fibronectin were induced during fibrosis stimulation. Baicalin reversed mRNA expressions in all four genes. Results are mean ± S.E.M. for each group. versus day 0 and ^# versus day 8.