Baicalin Ameliorates Experimental Liver Cholestasis in Mice by Modulation of Oxidative Stress, Inflammation, and NRF2 Transcription Factor

Figure 9

Schematic diagram of baicalin-mediated protection in experimental cholestatic liver injury. Bile duct ligation of healthy liver leads to hepatocyte cell death and oxidative stress. Both of these factors lead to proinflammatory responses, and significant inflammation occurs. Inflammation also leads to increased oxidative stress and thus interplay each other. Baicalin protects against cell death, oxidative stress, and inflammation. In addition to that, stellate cell activation occurs which leads to liver fibrosis. Under in vitro condition, baicalin attenuates stellate cell activation. All the above pathophysiological conditions lead to fibrotic liver.