Oxidative Medicine and Cellular Longevity / 2017 / Article / Fig 9

Research Article

Baicalin Ameliorates Experimental Liver Cholestasis in Mice by Modulation of Oxidative Stress, Inflammation, and NRF2 Transcription Factor

Figure 9

Schematic diagram of baicalin-mediated protection in experimental cholestatic liver injury. Bile duct ligation of healthy liver leads to hepatocyte cell death and oxidative stress. Both of these factors lead to proinflammatory responses, and significant inflammation occurs. Inflammation also leads to increased oxidative stress and thus interplay each other. Baicalin protects against cell death, oxidative stress, and inflammation. In addition to that, stellate cell activation occurs which leads to liver fibrosis. Under in vitro condition, baicalin attenuates stellate cell activation. All the above pathophysiological conditions lead to fibrotic liver.

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.