Research Article

Salvianolic Acid A Inhibits OX-LDL Effects on Exacerbating Choroidal Neovascularization via Downregulating CYLD

Figure 1

OX-LDL increases laser-induced CNV volume and leakage areas, and Sal A pretreatment antagonizes effects of OX-LDL. C57 mice were divided into PBS, OX-LDL, Sal A, and OX-LDL + Sal A groups. Each group was injected with PBS or OX-LDL or PBS administration. (a–d) Representative fluorescein angiograms 7 days postphotocoagulation showing late-phase leakages beyond borders. (a) Control group; (b) OX-LDL-injected group; (c) OX-LDL + Sal A-injected group; (d) Sal A-injected group. (e) Leakage areas of grade 4 lesions on the late phase of flourescein angiograms in each group. Leakage areas of grade 4 CNV lesions were measured by tracing the borders of fluorescein leakage using Image J software. Data were expressed as mean ± SEM. OX-LDL injection significantly increased a leakage area compared with the PBS group, and the OX-LDL + Sal A group had a smaller leakage area than the OX-LDL group ( versus the OX-LDL group).
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