Comparison of Effects of Different Statins on Contrast-Induced Acute Kidney Injury in Rats: Histopathological and Biochemical Findings

<div>Effects of statins on renal inflammation in a rat model of CI-AKI. Relative mRNA levels of (a) IL-6, (b) MCP-1, and (c) TNF-<i>α</i> were assessed in kidney tissue, using tissue, as an internal control. Results are expressed as mean ± SEM of three independent experiments. <svg height="15.3614pt" id="M72" style="vertical-align:-3.833899pt" version="1.1" viewbox="-0.0498162 -11.5275 54.2341 15.3614" width="54.2341pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M457 455H370L403 612H360L326 455H218L252 612H210L175 455H77L68 394H161L132 257H31L20 196H117L77 19H120L159 196H268L230 19H272L311 196H402L412 257H325L355 394H447L457 455ZM313 394L283 257H175L204 394H313Z" id="g58-33"></path><glyph.data ascent="1007" descent="-369" horiz-adv-x="487" vert-adv-y="487"></glyph.data></g><g transform="matrix(.0091,0,0,-0.0091,4.432,-5.741)"><path d="M457 455H370L403 612H360L326 455H218L252 612H210L175 455H77L68 394H161L132 257H31L20 196H117L77 19H120L159 196H268L230 19H272L311 196H402L412 257H325L355 394H447L457 455ZM313 394L283 257H175L204 394H313Z" id="g58-33"></path><glyph.data ascent="1007" descent="-369" 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ATO: atorvastatin; CI-AKI: contrast-induced acute kidney injury; IL-6: interleukin-6; MCP: monocyte chemotactic protein-1; RUS: rosuvastatin; SSTN: simvastatin; TNF-<i>α</i>: tumor necrosis factor-<i>α</i>.</div>

Oxidative Medicine and Cellular Longevity

fig3

Figure 3

Figure 3: Comparison of Effects of Different Statins on Contrast-Induced Acute Kidney Injury in Rats: Histopathological and Biochemical Findings 