Mitochondria-Targeted Antioxidants SkQ1 and MitoTEMPO Failed to Exert a Long-Term Beneficial Effect in Murine Polymicrobial Sepsis

Figure 2

Comparison of circulating cytokines between SkQ1-, MitoTEMPO-, and placebo-treated control mice. (a–g) Plasma levels of TNF-α, IL-1β, IL-5, IL-6, IL-10, IL-12p70, and IFN-γ in treated mice (SkQ1 or MitoTEMPO) at 6, 24, 48, and 72 h post-CLP were compared to the placebo group (CLP + NaCl). For (a–g): at 6 h: control  ≥ 19, SkQ1 , MitoTEMPO ; at 24 h: control , SkQ1 , MitoTEMPO ; at 48 h: control , SkQ1 , MitoTEMPO ; at 72 h: control , SkQ1 , MitoTEMPO . Data points shown as mean ± SEM. The exemplary IL-10 inset depicts scatter plot of all groups at 6 h post-CLP time point. 2 k (for brevity) corresponds to 2000 pg/ml.

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