Mitochondria-Targeted Antioxidants SkQ1 and MitoTEMPO Failed to Exert a Long-Term Beneficial Effect in Murine Polymicrobial Sepsis

Figure 4

Comparison of organ function parameters between SkQ1-, MitoTEMPO-, and placebo-treated control mice. Plasma levels of treated mice (SkQ1 or MitoTEMPO) of (a) urea, (b) ALT, (c) glucose, and (d) LDH in mice at baseline and post-CLP were compared to the control group (CLP + placebo). For (a–d): at BL ; at 6 h control , SkQ1 , MitoTEMPO ; at 24 h control , SkQ1 , MitoTEMPO ; at 48 h control , SkQ1 , MitoTEMPO ; at 72 h control , SkQ1 , MitoTEMPO . Data points shown as mean ± SEM.

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