Edaravone, a Synthetic Free Radical Scavenger, Enhances Alteplase-Mediated Thrombolysis

Table 1

Therapeutic Effects and Laboratory Data in the Rat Thromboembolic Ischemic Model.


	Control	Alteplase	Edaravone-alteplase combination
	n	n	n

Total number of rats
	8	8	8
Neurological score after awakening
3	5	4	3
4	3	4	5
Hemorrhagic transformation
	0	2	0
Blood test data
AST (U/L)	233.0 ± 241.5	182.5 ± 30.0	234.4 ± 125.1
ALT (U/L)	34.0 ± 11.8	34.4 ± 3.9	42.3 ± 19.2
BUN (mg/dl)	12.4 ± 1.3	13.2 ± 1.4	13.4 ± 1.9
Cr (mg/dl)	0.18 ± 0.07	0.18 ± 0.05	0.19 ± 0.07

Blood test data are shown as mean ± standard deviation. BUN: blood urea nitrogen; Cr: creatinine; AST: aspartate transaminase; ALT: alanine transaminase.

Oxidative Medicine and Cellular Longevity

Edaravone, a Synthetic Free Radical Scavenger, Enhances Alteplase-Mediated Thrombolysis

Table 1