Histopathological Changes in the Kidney following Congestive Heart Failure by Volume Overload in Rats

Figure 2

Light microscopic photographs of representative kidney sections of control and ACF adult rats. (a) and (b) show control haematoxylin-eosin- (a) and toluidine blue-stained (b) rat kidney with normal distal (thin arrow), proximal (thick arrow) tubular and glomerulus (G) structures are seen in the medulla of control kidney. (c) and (d) show ACF haematoxylin-eosin- (c) and toluidine blue-stained (d) rat kidney with histopathological changes in atrophic glomeruli (G) with atrophic changes such as widening of Bowman’s space with haemolysis, necrosis with obvious degeneration in nuclei, and apoptotic cell death. Also, histopathological changes in atrophic distal (thin arrow) and proximal (thick arrow) tubular structures are shown with epithelial shedding and loss of brush border of proximal tubules as well as desquamation of tubular epithelium of distal tubules in the medulla. (a), (c): ×120; (b), (d): ×200.

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