Are Antioxidants a Potential Therapy for FSHD? A Review of the Literature

Figure 2

Schematic of the transcriptional cascade effect of DUX4 in which it increases sensitivity to oxidative stress, inflammation, and apoptosis; impairs skeletal muscle contraction; and results in a myoblast differentiation defect. PITX1 = pituitary homeobox 1; P53 = tumour protein 53; MyoD = myogenic differentiation.