Centella asiatica Attenuates Mitochondrial Dysfunction and Oxidative Stress in Aβ-Exposed Hippocampal Neurons

Figure 1

CAW attenuates Aβ-induced oxidative stress and activates antioxidant response pathway in Tg2576 and WT hippocampal neurons. (a) Levels of intracellular reactive oxygen species (ROS) were elevated in Tg2576 neurons, and this increase was attenuated by CAW treatment (50 μg/mL; ). (b) CAW treatment reduced the increase in lipid peroxidation observed in Tg2576 neurons, as quantified by TBARs (). (c) CAW induced the expression of NRF2 and its target antioxidant genes in both Tg2576 and WT neurons (). compared to WT control unless otherwise indicated.

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