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Oxidative Medicine and Cellular Longevity
Volume 2017, Article ID 7038789, 14 pages
https://doi.org/10.1155/2017/7038789
Clinical Study

Actinidia chinensis Planch. Improves the Indices of Antioxidant and Anti-Inflammation Status of Type 2 Diabetes Mellitus by Activating Keap1 and Nrf2 via the Upregulation of MicroRNA-424

1Department of Geriatrics, The First Affiliated Hospital of China Medical University, Shenyang 110001, China
2Department of Emergency Medicine, The First Affiliated Hospital of China Medical University, Shenyang 110001, China
3Department of Urology, Liaoning Cancer Hospital and Institute, Shenyang 110042, China

Correspondence should be addressed to Longfeng Sun; ten.haey@2101flnus

Received 24 December 2016; Revised 24 February 2017; Accepted 19 March 2017; Published 31 May 2017

Academic Editor: Jaideep Banerjee

Copyright © 2017 Longfeng Sun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The fruit juice of Actinidia chinensis Planch. has antioxidant and anti-inflammation properties on patients with type 2 diabetes mellitus (T2DM), but the molecular mechanism was unclear. The patients took the juice and the serum level of antioxidant miR-424, Kelch-like ECH-associated protein 1 (Keap1), erythroid-derived 2-like 2 (Nrf2), and biochemical indices were measured. The juice increased the levels of serum microRNA-424, Keap1, and Nrf2 and reduced the levels of interleukin-1 (IL-1) beta and IL-6 in T2DM patients. The levels of SOD and GSH were higher while the levels of ALT and AST were lower in the patients consuming the juice when compared to the patients without taking the juice. The Spearman rank correlation analysis showed that the serum levels of miR-424 were positively related to Keap1 and Nrf2 levels while Keap1 and Nrf2 levels were positively related to the levels of SOD and GSH and negatively related to IL-1 beta and IL-6. Thus, FJACP improves the indices of antioxidant and anti-inflammation status by activating Keap1 and Nrf2 via the upregulation of miR-424 in the patients with T2DM. This trial is registered with ChiCTR-ONC-17011087 on 04/07/2017.