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Oxidative Medicine and Cellular Longevity
Volume 2017, Article ID 7083049, 19 pages
Review Article

The Combination of Physical Exercise with Muscle-Directed Antioxidants to Counteract Sarcopenia: A Biomedical Rationale for Pleiotropic Treatment with Creatine and Coenzyme Q10

1Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy
2Department of Life and Environmental Sciences (DISVA), Marche Polytechnic University, Ancona, Italy
3Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy
4Department for Life Quality Studies, Alma Mater Studiorum, University of Bologna, Rimini, Italy

Correspondence should be addressed to Piero Sestili; ti.bruinu@ilitses.oreip

Received 5 June 2017; Revised 13 August 2017; Accepted 23 August 2017; Published 20 September 2017

Academic Editor: Guilherme Bresciani

Copyright © 2017 Michele Guescini et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Sarcopenia represents an increasing public health risk due to the rapid aging of the world’s population. It is characterized by both low muscle mass and function and is associated with mobility disorders, increased risk of falls and fractures, loss of independence, disabilities, and increased risk of death. Despite the urgency of the problem, the development of treatments for sarcopenia has lagged. Increased reactive oxygen species (ROS) production and decreased antioxidant (AO) defences seem to be important factors contributing to muscle impairment. Studies have been conducted to verify whether physical exercise and/or AOs could prevent and/or delay sarcopenia through a normalization of the etiologically relevant ROS imbalance. Despite the strong rationale, the results obtained were contradictory, particularly with regard to the effects of the tested AOs. A possible explanation might be that not all the agents included in the general heading of “AOs” could fulfill the requisites to counteract the complex series of events causing/accelerating sarcopenia: the combination of the muscle-directed antioxidants creatine and coenzyme Q10 with physical exercise as a biomedical rationale for pleiotropic prevention and/or treatment of sarcopenia is discussed.