Picroside II Shows Protective Functions for Severe Acute Pancreatitis in Rats by Preventing NF-κB-Dependent Autophagy

Table 2

The histopathologic scores of SAP among different groups.

	Edema	Acinar cell necrosis	Hemorrhage	Inflammation and perivascular infiltration
Control	0^b,c,d,e	0^b,c,d,e	0^b,c,d,e	0^b,c,d,e
SAP model	3.5 ± 0.4^a,c,d,e	2.9 ± 0.5^a,c,d,e	3.0 ± 0.4^a,c,d,e	4.1 ± 0.6^a,c,d,e
Picroside II, 12.5 mg/kg	3.1 ± 0.3^a,b,d,e	2.7 ± 0.3^a,b,d,e	2.6 ± 0.3^a,b,d,e	3.5 ± 0.4^a,b,d,e
Picroside II, 25 mg/kg	2.5 ± 0.3^a,b,c	2.2 ± 0.2^a,b,c	2.3 ± 0.3^a,b,c	3.0 ± 0.4^a,b,c
Picroside II, 50 mg/kg	2.4 ± 0.2^a,b,c	2.0 ± 0.2^a,b,c	2.2 ± 0.2^a,b,c	2.8 ± 0.3^a,b,c

Note: control, healthy rats. SAP model, the rat model was induced with cerulean. Picroside II groups, SAP models were with different concentrations of picroside II. ^a versus the control group; ^b versus the SAP group; ^c versus the picroside II group (12.5 mg/kg); ^d versus the picroside II group (25 mg/kg); ^e versus the picroside II group (50 mg/kg).