Rosmarinic Acid Alleviates the Endothelial Dysfunction Induced by Hydrogen Peroxide in Rat Aortic Rings via Activation of AMPK

Figure 2

Rosmarinic acid alleviates the endothelial dysfunction induced by H₂O₂ in endothelium-intact rat aortic rings. (a) Rosmarinic acid (RA) pulse exposure showed no effect on the contraction induced by KCl in rat aortic rings. (b) Rosmarinic acid (RA) pulse exposure showed no effect on the contraction induced by PE in rat aortic rings. (c) Rosmarinic acid (RA) preincubation alleviated the endothelium-dependent vasodilation impairments induced by H₂O₂. (d) Rosmarinic acid (RA) cotreatment inhibited the NBT reduction induced by H₂O₂ in the endothelium-intact aortic rings. The results were expressed as the means ± SD (). versus the untreated control group; ^## versus the H₂O₂-treated group.

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