The Antioxidant Machinery of Young and Senescent Human Umbilical Vein Endothelial Cells and Their Microvesicles

Figure 1

Diagram showing the main components of the peptide-involving antioxidant machinery. CAT: catalase; GPX: glutathione peroxidase; GRX: glutaredoxin; GSR: glutathione reductase; GST: glutathione S-transferase (K: kappa; O: omega; P: pi; T: theta); HMOX: heme oxygenase; mGST: microsomal glutathione S-transferase; PRDX: peroxiredoxin; SOD: superoxide dismutase; TMX: thioredoxin-related transmembrane protein; TRX: thioredoxin; TRXR: thioredoxin reductase. NADPH-synthesizing enzymes: G6PD: glucose-6-phosphate dehydrogenase; GLUD: glutamate dehydrogenase; IDH: isocitrate dehydrogenase; PGD: 6-phosphogluconate dehydrogenase.