Novel Therapeutic Effects of Leonurine On Ischemic Stroke: New Mechanisms of BBB Integrity

Figure 1

Posttreatment with SCM-198 significantly protected against the damage induced by tMCAO. The rats were subjected to 90 min MCAO before reperfusion. SCM-198 decreased the infarct volume and improved neurological scores. (a) Representative pictures of coronal sections from ischemic rat brain stained with TTC. (b) The quantitative analysis of the number of infarct size. F (4, 31) = 35.04, . (c–e) Neurological function was ameliorated by SCM-198 after ischemia reperfusion. Values are expressed as mean ± SEM. ^# versus the control group, versus the tMCAO group, . Posttreatment with SCM-198 maintained BBB integrity. (f, g) At the end of treatment, the Evans blue dye was injected into the vein following 24 h circulation. (f) Representative pictures of coronal sections from rat brain stained with Evans blue dye after ischemic reperfusion. (g) The quantitative analysis of Evans blue leakage after ischemia reperfusion, F (3, 39) = 59.33, . Edema volume ((h), F (3, 20) = 29.14, ) and water content ((i), F (3, 52) = 18.06, ) were decreased by SCM-198 after ischemia reperfusion. Values are expressed as mean ± SEM. ^# versus the control group, versus the tMCAO group, .

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