Research Article
Mitochondrial Uncoupler Prodrug of 2,4-Dinitrophenol, MP201, Prevents Neuronal Damage and Preserves Vision in Experimental Optic Neuritis
Figure 1
MP201 preserves RGC function. Visual function, measured by OKR responses, shows significant () decreases in eyes of EAE mice () compared to control mouse eyes () by 6 weeks after induction of EAE. Daily oral treatment of 16 mg/kg MP201 () from days 15 to 42 postimmunization leads to significantly (@@ versus EAE) improved OKR responses in EAE mice. Mice receiving 80 mg/kg MP201 daily () show initial vision loss by week 3 that then reverses with improved OKR score in subsequent weeks.