Therapeutic Potential of Novel Twin Compounds Containing Tetramethylpyrazine and Carnitine Substructures in Experimental Ischemic Stroke

<div>Both LR134 and LR143 protected against cerebral ischemia reperfusion (I/R) injury in rats. (a) Representative photographs of TTC staining and calculated infarct volume showing the effects of candidate 2-hydroxymethyl-3,5,6-trimethylpyrazine-carnitine ester twin compounds in rats with cerebral I/R injury. (b) Neurological deficit scores in ischemic rats with different treatments. (c) The cerebral edema index in ischemic rats with different treatments. 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Oxidative Medicine and Cellular Longevity

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Figure 3

Figure 3: Therapeutic Potential of Novel Twin Compounds Containing Tetramethylpyrazine and Carnitine Substructures in Experimental Ischemic Stroke 