Blood-Based Bioenergetic Profiling Reflects Differences in Brain Bioenergetics and Metabolism

Table 2

Respiratory parameters for monocytes, platelets, and isolated brain mitochondria.

	Mean	SD
Monocyte respiration (pmol/min/250,000 cells)
Basal	50.64	20.82
Maximal	98.65	42.80
Leak	6.25	9.30
Nonmitochondrial	22.08	14.02
Reserve	48.02	27.56
Bioenergetic health index	1.58	1.50
Platelet respiration (pmol/min/mg protein)
Basal	210.04	87.71
Maximal	419.93	161.31
Leak	17.95	28.38
Nonmitochondrial	85.92	20.76
Reserve	209.88	88.46
Bioenergetic health index	2.40	0.85
Brain-isolated mitochondria (pmol/min/5 μg mitochondrial protein)
State 3	250.31	112.86
State 4o	66.01	46.83
Maximal FCCP-linked	268.42	102.87
Nonmitochondrial	22.58	42.50

Monocyte: ; platelet: ; isolated brain mitochondria: .