Research Article

Commiphora molmol Modulates Glutamate-Nitric Oxide-cGMP and Nrf2/ARE/HO-1 Pathways and Attenuates Oxidative Stress and Hematological Alterations in Hyperammonemic Rats

Table 2

Effect of C. molmol on ammonia, liver function marker enzymes, and TNF-α in control and hyperammonemic rats.

ControlC. molmolNH4ClNH4Cl + C. molmol

Ammonia (μmol/dL)75.30 ± 6.2372.69 ± 4.89418.20 ± 18.48136.25 ± 8.79###
ALT (U/L)28.78 ± 4.2526.50 ± 2.4864.81 ± 6.2336.12 ± 3.14###
AST (U/L)53.45 ± 4.2648.16 ± 3.89132.71 ± 8.4968.51 ± 6.77###
ALP (U/L)82.69 ± 6.1384.26 ± 5.23179.18 ± 10.2695.50 ± 7.56###
TNF-α (pg/mL)32.60 ± 2.4235.78 ± 3.8878.59 ± 5.5348.36 ± 4.33##

Data are expressed as mean ± SEM (). versus control, and ## and ### versus NH4Cl.