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Oxidative Medicine and Cellular Longevity
Volume 2017, Article ID 7371010, 13 pages
https://doi.org/10.1155/2017/7371010
Review Article

Eag1 K+ Channel: Endogenous Regulation and Functions in Nervous System

1Department of General Surgery, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China
2Hongqiao International Institute of Medicine, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China
3Center for Life Sciences, National Laboratory Astana and School of Sciences and Technology, Nazarbayev University, Astana 010000, Kazakhstan
4Department of Anesthesiology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China

Correspondence should be addressed to Shangwei Hou; nc.ude.utjs@wsuoh

Received 14 November 2016; Revised 27 December 2016; Accepted 31 January 2017; Published 6 March 2017

Academic Editor: Rodrigo Franco

Copyright © 2017 Bo Han et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Ether-à-go-go1 (Eag1, Kv10.1, KCNH1) K+ channel is a member of the voltage-gated K+ channel family mainly distributed in the central nervous system and cancer cells. Like other types of voltage-gated K+ channels, the EAG1 channels are regulated by a variety of endogenous signals including reactive oxygen species, rendering the EAG1 to be in the redox-regulated ion channel family. The role of EAG1 channels in tumor development and its therapeutic significance have been well established. Meanwhile, the importance of hEAG1 channels in the nervous system is now increasingly appreciated. The present review will focus on the recent progress on the channel regulation by endogenous signals and the potential functions of EAG1 channels in normal neuronal signaling as well as neurological diseases.