Plasma DNA Mediate Autonomic Dysfunctions and White Matter Injuries in Patients with Parkinson’s Disease
Table 1
Demographic characteristics of PD patients and control subjects.
PD
Normal control
Number
29
26
Sex (M : F)
20 : 9
19 : 7
0.775
Age
61.51 ± 8.27
60.11 ± 7.77
0.521
UPDRS I
3.96 ± 2.97
UPDRS II
12.21 ± 7.26
UPDRS III
27.03 ± 13.20
UPDRS 176
43.10 ± 21.93
Modified Hoehn and Yahr staging
2.36 ± 0.97
Schwab and England (S&E) scale
81.03 ± 13.98
Oxidative stress biomarkers
Nuclear DNA (ng/mL)
41.31 ± 29.95
10.92 ± 8.17
Mitochondrial DNA (ng/mL)
42.70 ± 26.01
24.56 ± 28.80
Autonomic parameters
HR_DB
7.38 ± 8.35
8.96 ± 6.00
0.480
BRS
4.40 ± 2.62
6.24 ± 3.18
LF/HF ratio
2.15 ± 2.00
1.77 ± 1.52
0.549
LF
54.94 ± 24.76
52.60 ± 22.91
0.815
HF
45.05 ± 24.76
47.33 ± 22.98
0.821
Sex data were compared by Pearson chi-square test. Age data were compared by independent -test. Oxidative stress biomarkers and autonomic parameters were compared by analysis of covariance (ANCOVA) after controlling for age and sex. Data are presented as mean ± standard deviation. . PD, Parkinson’s disease; HR_DB, heart rate response to deep breathing; BRS, baroreflex sensitivity; LF, low frequency; HF, high frequency.
