Plasma DNA Mediate Autonomic Dysfunctions and White Matter Injuries in Patients with Parkinson’s Disease

Table 2

Regions showing fractional anisotropy differences between patients with Parkinson’s disease (PD) and control subjects (NC).

MNI atlas coordinates			Voxel size	White matter tract	FA mean (SD),			Diffusivity values (PD-NC) (×10^−6)
					Controls	PD		MD ()	AD ()	RD ()
				Decreased FA in PD patients versus Controls
−26	−63	33	1914	Parietal WM, left	0.449 (0.031)	0.406 (0.034)	4.46	27	−9	44
−22	−53	−38	2698	Middle cerebellar peduncle, left	0.427 (0.023)	0.339 (0.026)	4.41	2	−27	17
−24	−87	6	647	Inferior longitudinal fasciculus, left occipital lobe	0.375 (0.027)	0.338 (0.023)	4.05	30	−12	51
27	−61	32	522	Inferior longitudinal fasciculus, right parietal lobe	0.425 (0.033)	0.381 (0.045)	3.49	29	−14	50
−9	−35	32	2350	Cingulum, left	0.642 (0.030)	0.612 (0.025)	3.45	35	21	42
20	42	4	902	Forceps minor, right frontal lobe	0.474 (0.033)	0.432 (0.048)	3.44	17	−34	43
−12	30	42	203	Superior longitudinal fasciculus, left frontal lobe	0.349 (0.030)	0.319 (0.029)	3.38	25	3	35
3	−20	−7	563	Midbrain	0.364 (0.034)	0.327 (0.043)	3.21	230	236	228

Location of maximum effect (uncorrected , cluster size >200) was shown in the Montreal Neurological Institute (MNI) space.
Group FA mean values in each cluster are presented as mean (standard deviation).
Passing the AlphaSim correction (, cluster size >1871) is identified by italic.
The FA, MD, AD, and RD values in the regions of interest were further compared between two groups by analysis of covariance after controlling for age, sex, and education.
with a Bonferroni correction, accounting for multiple ROI comparisons.
WM, white matter; FA, fractional anisotropy; AD, axial diffusivity; MD, mean diffusivity; RD, radial diffusivity.