Acarbose Accelerates Wound Healing via Akt/eNOS Signaling in db/db Mice
Acarbose ameliorated EPC function and suppressed intracellular ROS levels via an Akt dependent pathway in vitro. Acarbose (1 μM) and p-Akt inhibitor and MK-2206 (1 μM) were added to the high glucose medium for 24 h. Measurement of tube formation (a), migration (b), and adhesion (c) capacity of BM-EPCs. Determination of intracellular NO level (d) and level (e). , , and . Values are expressed as the mean ± standard deviation ((a), (b), (c): per group; (d), (e): per group). Scale bar = 100 μm. Con, control; HG, high glucose; Aca, acarbose; MK, MK-2206.
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