Pitaya Extracts Induce Growth Inhibition and Proapoptotic Effects on Human Cell Lines of Breast Cancer via Downregulation of Estrogen Receptor Gene Expression
Table 3
Effect of PE on cell cycle progression in MCF-7 and MDA-MB-435 cells after 24 h and 48 h exposure.
Cell line
Incubation time
Cell cycle phases
Control (CT)
500 μg/mL
1000 μg/mL
MCF-7
24 h
G0/G1
59.59 ± 0.16
63.47 ± 2.07
65.02 ± 0.23
S
16.91 ± 1.20
14.03 ± 0.61
14.80 ± 2.36
G2/M
19.28 ± 1.87
19.77 ± 1.42
17.48 ± 3.22
48 h
G0/G1
58.49 ± 0.45
65.40 ± 1.10
69.61 ± 3.90
S
16.45 ± 0.55
10.63 ± 0.25
13.64 ± 1.71
G2/M
22.28 ± 0.93
20.19 ± 0.04
15.66 ± 3.72
MDA-435
24 h
G0/G1
62.30 ± 1.12
61.99 ± 1.99
61.60 ± 0.64
S
14.84 ± 0.43
14.93 ± 0.24
14.87 ± 0.51
G2/M
19.90 ± 1.29
19.83 ± 2.04
18.88 ± 0.68
48 h
G0/G1
69.64 ± 1.18
70.64 ± 0.80
70.01 ± 1.85
S
11.88 ± 0.89
11.30 ± 0.62
11.50 ± 0.53
G2/M
15.17 ± 1.03
15.52 ± 0.52
15.76 ± 0.83
The cell cycle phases and quantitative results are illustrated in accordance with the exposure time and PE concentration. The experiment is expressed as mean ± error standard. indicates significant differences from the control group (; ).
