Impact of Yoga and Meditation on Cellular Aging in Apparently Healthy Individuals: A Prospective, Open-Label Single-Arm Exploratory Study
Table 3
Change in outcomes in apparently healthy sedentary subjects participating in a Yoga and Meditation based lifestyle intervention ().
Characteristics
Baseline
12 wks
Change from baseline to 12 wks (diff. 95% C.I.)
Effect
p value
Primary endpoints: cardinal biomarkers of cellular aging
Oxidative stress
ROS (RLU/min/104 neutrophils)
194.3 (164, 224.5)
0.7
<0.0001
TAC (mmol Trolox equiv/L)
−1.16 (−1.9, −0.41)
0.4
<0.001
DNA damage
8OH2dG (pg/mL)
235.3 (72.73, 397.8)
0.22
<0.01
Telomere attrition
Telomerase activity (IU/cell)
−1.05 (−1.68, −0.41)
0.3
<0.001
Telomere length (IU/cell)
−0.08 (−0.61, 0.45)
0.02
0.069
Secondary endpoints: biomarkers associated with cellular aging
Cortisol (ng/mL)
22.51 (7.6, 37.42)
0.3
<0.01
Interleukin (IL6) (pg/mL)
1.22 (0.47, 1.97)
0.3
<0.001
-Endorphins (ng/mL)
−2 (−3.22, −0.77)
0.3
<0.001
BDNF (ng/mL)
−17.4 (−19.48, −15.32)
0.7
<0.0001
Sirtuin (ng/mL)
40.64 ± 11.6
−13.95 (−23.41, −4.49)
0.5
<0.01
BMI (kg/m2)
2.66 (0.56, 3.12)
0.4
<0.01
size was calculated by dividing change by standard deviation at baseline of the specific outcome and interpreted using Cohen’s d (small effect: 0.2 to 0.3, medium effect: 0.5, and large effect: 0.8).
