Table 3: Change in outcomes in apparently healthy sedentary subjects participating in a Yoga and Meditation based lifestyle intervention ().

CharacteristicsBaseline 12 wksChange from baseline to 12 wks
(diff. 95% C.I.)
Effect p value

Primary endpoints: cardinal biomarkers of cellular aging
Oxidative stress
 ROS (RLU/min/104 neutrophils)194.3 (164, 224.5)0.7<0.0001
 TAC (mmol Trolox equiv/L)−1.16 (−1.9, −0.41)0.4<0.001
DNA damage
 8OH2dG (pg/mL)235.3 (72.73, 397.8)0.22<0.01
Telomere attrition
 Telomerase activity (IU/cell)−1.05 (−1.68, −0.41)0.3<0.001
 Telomere length (IU/cell)−0.08 (−0.61, 0.45)0.020.069
Secondary endpoints: biomarkers associated with cellular aging
 Cortisol (ng/mL)22.51 (7.6, 37.42)0.3<0.01
 Interleukin (IL6) (pg/mL)1.22 (0.47, 1.97)0.3<0.001
-Endorphins (ng/mL)−2 (−3.22, −0.77)0.3<0.001
 BDNF (ng/mL)−17.4 (−19.48, −15.32)0.7<0.0001
 Sirtuin (ng/mL)40.64 ± 11.6−13.95 (−23.41, −4.49)0.5<0.01
BMI (kg/m2)2.66 (0.56, 3.12)0.4<0.01

size was calculated by dividing change by standard deviation at baseline of the specific outcome and interpreted using Cohen’s d (small effect: 0.2 to 0.3, medium effect: 0.5, and large effect: 0.8).