Treatment of the Fluoroquinolone-Associated Disability: The Pathobiochemical Implications

Table 1

The conversion of Nernst equation for bivalent ions as Mg²⁺, Mn²⁺, Fe²⁺, and Zn²⁺ shows strong relation between the actual membrane potential and ability of the cell/mitochondrium to attract and absorb the ions into the cell/mitochondrium. Reduced membrane potential ΔV is a strong factor which hinders entering bivalent cations to the cell. However, the detailed mechanisms of individual ion transport must be analyzed.

ΔV/ΔΨm	Equilibrium cin/cout gradient ( and K)
−160 mV	160.000x
−140 mV	36.000x
−110 mV	3.800x
−90 mV	850x
−70 mV	190x
−50 mV	42x
−30 mV	9x