Oxidative Medicine and Cellular Longevity / 2017 / Article / Tab 1

Review Article

Modulatory Mechanism of Polyphenols and Nrf2 Signaling Pathway in LPS Challenged Pregnancy Disorders

Table 1

Some enlisted Nrf2 gene regulation in maternofetal tissues.

OriginRegulation of Nrf2 protein/geneFunctional significanceReferences

Human umbilical endothelial cellsNQO1, GCLM, Nrf2, GSK3βGDM ↑ oxidative stress and ↓ Nrf2 activity and overexpression of antioxidant expression[112]
RatNrf2, HO-1, SOD2Hydroxytyrosol (HT) and moderate
Restraint stress (GD14-20) ↑ Nrf2-dependent gene expression
Rat liverGSTP, Nrf2Maternal perfluorooctane sulfonate ↑ methylation of Nrf2-dependent GSTP gene promoter[114]
Nrf2−/− and WT miceNrf2, GSTA3, MGST1, GSTA4
Gpx2, AKR1B1, AKR1B10, NQO1
Postnatal hyperoxia ↑ Nrf2-dependent gene expression, abolished in Nrf2−/− mice[115]
Mouse embryosNrf2, SOD1, SOD2, SOD3, CAT, Trx, Gpx1, Gpx2, Gpx3, GRMaternal ethanol or D3T exposure ↑ Nrf2-dependent gene expression[116]
Mouse embryosGSH, NQO1, HO-1, GCLC, GST, Prx1
Trx1, Trx2
Maternal D3T administration ↑ Nrf2-dependent gene and ↓ H2O2-induced Trx1 and Trx2 oxidation[117]

AKR1B1: aldo-keto reductase family-1 member B1 (aldose reductase); AKR1B10: aldo-keto reductase family-10 member B10 (aldose reductase); CAT: Catalase); GCLC: glutamate-cysteine ligase catalytic subunit enzyme; GCLM: glutamate-cysteine ligase regulatory subunit enzyme; GDM: gestational diabetes mellitus; GR: glutathione reductase; GSK3β: glycogen synthase kinase 3 beta; GSH: glutathione peroxidase; GSTA3: glutathione S-transferase alpha-4; GSTA4: glutathione S-transferase alpha-4; Gpx1, 2, and 3: glutathione peroxidase 1, 2, and 3; GST: glutathione S-transferase; GSTP: glutathione reductase; GPO: glutathione peroxidase; HO-1: heme oxygenase; MGST1: microsomal glutathione S-transferase 1; NQO1: (NAD(P)H:quinone dehydrogenase 1; Nrf2: NF-E2-related factor 2; Prx1: peroxiredoxin 1; SOD1, 2, and 3: sodium dismutase 1, 2, and 3; Trx1 and 2: thioredoxin-1 and 2).