Table 2
Beneficial effects of polyphenols in LPS-induced pregnancy disorders.
| | LPS doses | Gestation stages (days) | Pregnancy disorders | Flavonoids/protective effects | References |
| | LPS 0.2 mL/0.2 μg/mouse | 4–7 | Abortion | Quercetin indicates antiabortive effects through influence on CD4+/CD8+ T lymphocytes and IFN and IL-4 | [136] | | LPS 0.1 μg per mouse | 6.7 | Fetal resorption | Polyphenolic compounds of Radix Scutellariae and Rhizoma Atractylodis (baicalein, wogonin, oroxylin, baicalin, wogonoside, oroxylin A-7-glucuronide reduced fetal resorption and including IL-10
Pharmacological effects and pharmacokinetic properties of Radix Scutellariae and its bioactive flavones | [137, 138] | | LPS, 0.1 mL/10 g in vitro/in vivo | 6
6 & 7 | Injury of decidual cells | Baicalin, 4 μg/mL in vitro and in vivo at different doses prevents decidual cell injury by inhibition of TNF-α | [68] | | LPS at 0.2 ml, murine model | 7 | Abortion and reabsorption | Bao Tai Wu You, Tai Shan Pan Shi, or Bai Zhu San at 0.5 ml oral medication for 7 days ameliorates INF-γ and increases IL-10 and IL-4 thus showing beneficial effects | [139] |
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CD4 and 8: cluster of differentiation 4 and 8; IFN: interferon; IL-4: interleukine-4; IL-10: interleukine-10; INF-γ: interferon gamma; TNF-α: tumor necrosis factor-alpha.
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