Oxidative Medicine and Cellular Longevity / 2017 / Article / Tab 2

Review Article

Modulatory Mechanism of Polyphenols and Nrf2 Signaling Pathway in LPS Challenged Pregnancy Disorders

Table 2

Beneficial effects of polyphenols in LPS-induced pregnancy disorders.

LPS dosesGestation stages (days)Pregnancy disordersFlavonoids/protective effectsReferences

LPS 0.2 mL/0.2 μg/mouse4–7AbortionQuercetin indicates antiabortive effects through influence on CD4+/CD8+ T lymphocytes and IFN and IL-4[136]
LPS 0.1 μg per mouse6.7Fetal resorptionPolyphenolic compounds of Radix Scutellariae and Rhizoma Atractylodis (baicalein, wogonin, oroxylin, baicalin, wogonoside, oroxylin A-7-glucuronide reduced fetal resorption and including IL-10
Pharmacological effects and pharmacokinetic properties of Radix Scutellariae and its bioactive flavones
[137, 138]
LPS, 0.1 mL/10 g in vitro/in vivo6
6 & 7
Injury of decidual cellsBaicalin, 4 μg/mL in vitro and in vivo at different doses prevents decidual cell injury by inhibition of TNF-α[68]
LPS at 0.2 ml, murine model7Abortion and reabsorptionBao Tai Wu You, Tai Shan Pan Shi, or Bai Zhu San at 0.5 ml oral medication for 7 days ameliorates INF-γ and increases IL-10 and IL-4 thus showing beneficial effects[139]

CD4 and 8: cluster of differentiation 4 and 8; IFN: interferon; IL-4: interleukine-4; IL-10: interleukine-10; INF-γ: interferon gamma; TNF-α: tumor necrosis factor-alpha.