Modulatory Mechanism of Polyphenols and Nrf2 Signaling Pathway in LPS Challenged Pregnancy Disorders

Table 2

Beneficial effects of polyphenols in LPS-induced pregnancy disorders.

LPS doses	Gestation stages (days)	Pregnancy disorders	Flavonoids/protective effects	References
LPS 0.2 mL/0.2 μg/mouse	4–7	Abortion	Quercetin indicates antiabortive effects through influence on CD4+/CD8+ T lymphocytes and IFN and IL-4	[136]
LPS 0.1 μg per mouse	6.7	Fetal resorption	Polyphenolic compounds of Radix Scutellariae and Rhizoma Atractylodis (baicalein, wogonin, oroxylin, baicalin, wogonoside, oroxylin A-7-glucuronide reduced fetal resorption and including IL-10; Pharmacological effects and pharmacokinetic properties of Radix Scutellariae and its bioactive flavones	[137, 138]
LPS, 0.1 mL/10 g in vitro/in vivo	6; 6 & 7	Injury of decidual cells	Baicalin, 4 μg/mL in vitro and in vivo at different doses prevents decidual cell injury by inhibition of TNF-α	[68]
LPS at 0.2 ml, murine model	7	Abortion and reabsorption	Bao Tai Wu You, Tai Shan Pan Shi, or Bai Zhu San at 0.5 ml oral medication for 7 days ameliorates INF-γ and increases IL-10 and IL-4 thus showing beneficial effects	[139]

CD4 and 8: cluster of differentiation 4 and 8; IFN: interferon; IL-4: interleukine-4; IL-10: interleukine-10; INF-γ: interferon gamma; TNF-α: tumor necrosis factor-alpha.