Chemical Composition and Pharmacological Effects of Geopropolis Produced by Melipona quadrifasciata anthidioides

Table 3

MIC and MBC/MFC values for HEG from M. q. anthidioides.

(a)

Microorganisms	HEG (mg/mL)		Gentamicin (μg/mL)
	MIC	MBC	MIC	MBC
Gram-positive bacteria
Staphylococcus aureus ATCC 6538	5.16 ± 0.22	7.33 ± 0.16	1.66 ± 0.16	2.0 ± 0.28
Methicillin-resistant S. aureus ESA 175	5.75 ± 0.14	7.83 ± 0.16	1.83 ± 0.16	2.66 ± 0.16
Methicillin-resistant S. aureus ESA 159	6.25 ± 0.14	8.08 ± 0.22	2.0 ± 0.28	2.50 ± 0.28
Enterococcus faecalis ATCC 43300	6.75 ± 0.14	8.75 ± 0.25	2.16 ± 0.16	2.83 ± 0.30
Vancomycin-resistant E. faecalis ESA 201	7.33 ± 0.83	9.50 ± 0.28	2.33 ± 0.16	3.25 ± 0.14
Vancomycin-resistant E. faecalis ESA 361	7.58 ± 0.30	9.91 ± 0.54	2.66 ± 0.16	3.33 ± 0.16
Gram-negative bacteria
Escherichia coli ATCC 29998	9.66 ± 0.44	13.0 ± 0.14	4.08 ± 0.08	4.58 ± 0.30
Cephalosporin-resistant E. coli ESA 37	10.25 ± 0.52	13.16 ± 0.44	4.66 ± 0.16	4.66 ± 0.22
Cephalosporin-resistant E. coli ESA 54	10.25 ± 0.25	13.33 ± 0.36	4.41 ± 0.08	4.91 ± 0.08
Pseudomonas aeruginosa ATCC 15442	11.91 ± 0.36	15.41 ± 0.36	4.75 ± 0.14	5.0 ± 0.28
Imipenem-resistant P. aeruginosa ESA 22	12.16 ± 0.60	15.41 ± 0.30	5.66 ± 0.16	6.61 ± 0.16
Imipenem-resistant P. aeruginosa ESA 23	12.75 ± 0.28	16.41 ± 0.36	6.66 ± 0.33	6.50 ± 0.28

(b)

Microorganisms	HEG (mg/mL)		Amphotericin B (μg/mL)
	MIC	MFC	MIC	MFC
Fungi
Cryptococcus neoformans ATCC 32264	18.08 ± 0.36	23.0 ± 0.14	0.55 ± 0.02	0.86 ± 0.07
Amphotericin B-resistant C. neoformans ESA 211	18.58 ± 0.71	24.08 ± 0.46	0.61 ± 0.06	1.25 ± 0.14
Amphotericin B-resistant C. neoformans ESA105	19.08 ± 0.82	24.25 ± 0.25	0.63 ± 0.01	1.66 ± 0.22
Candida albicans ATCC 10231	20.5 ± 0.28	28.25 ± 0.87	0.71 ± 0.04	0.91 ± 0.16
Amphotericin B-resistant C. albicans ESA 100	21.41 ± 0.54	29.33 ± 0.60	0.81 ± 0.04	1.66 ± 0.08
Amphotericin B-resistant C. albicans ESA 97	21.83 ± 0.44	31.08 ± 0.68	0.91 ± 0.01	1.75 ± 0.14