A Single Zidovudine (AZT) Administration Delays Hepatic Cell Proliferation by Altering Oxidative State in the Regenerating Rat Liver

Figure 5

Effects of AZT on parameters indicative of oxidant stress in microsomes (Endoplasmic Reticulum) obtained from livers at various times after 70% PH. Results are expressed as mean ± SE for four independent determinations per experimental point as nmoles⋅mg⁻¹ of protein in panels (a) and (b), or in pmoles⋅mg⁻¹ of protein (panel (c)). Symbols for the experimental groups at the bottom of each figure and the statistical significance as indicated in Figure 1.

(a) MDA

(b) Conjugated dienes

(c) Carbonyl groups