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Oxidative Medicine and Cellular Longevity
Volume 2017, Article ID 8370593, 14 pages
https://doi.org/10.1155/2017/8370593
Research Article

Myricetin Possesses Potential Protective Effects on Diabetic Cardiomyopathy through Inhibiting IκBα/NFκB and Enhancing Nrf2/HO-1

Hai-han Liao,1,2,3 Jin-xiu Zhu,1,2,3 Hong Feng,4 Jian Ni,1,2,3 Nan Zhang,1,2,3 Si Chen,2,3 Huang-jun Liu,1,2,3 Zheng Yang,1,2,3 Wei Deng,1,2,3 and Qi-Zhu Tang1,2,3

1Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China
2Cardiovascular Research Institute of Wuhan University, Wuhan, China
3Hubei Key Laboratory of Cardiology, Wuhan, China
4Department of Gerontology, Renmin Hospital of Wuhan University, Wuhan 430060, China

Correspondence should be addressed to Qi-Zhu Tang; nc.ude.uhw@gnatzq

Received 12 May 2017; Revised 18 July 2017; Accepted 26 July 2017; Published 24 September 2017

Academic Editor: Silvana Hrelia

Copyright © 2017 Hai-han Liao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [22 citations]

The following is the list of published articles that have cited the current article.

  • Xiao-Yu Liu, Hai-han Liao, Hong Feng, Nan Zhang, Jing-jing Yang, Wen-jing Li, Si Chen, Wei Deng, and Qi-Zhu Tang, “Icariside II attenuates cardiac remodeling via AMPKα2/mTORC1 in vivo and in vitro,” Journal of Pharmacological Sciences, 2018. View at Publisher · View at Google Scholar
  • Meng Wu, Yeping Yang, Meng Wang, Fangfang Zeng, Qin Li, Wenjuan Liu, Shizhe Guo, Min He, Yi Wang, Jie Huang, Linuo Zhou, Yiming Li, Ji Hu, Wei Gong, and Zhaoyun Zhang, “Exogenous Pancreatic Kallikrein Improves Diabetic Cardiomyopathy in Streptozotocin-Induced Diabetes,” Frontiers in Pharmacology, vol. 9, 2018. View at Publisher · View at Google Scholar
  • Shuai Teng, Chen Wang, Zhe Meng, Xue-Yang Bai, and Hai-Yu Li, “Asiatic acid inhibits cardiac fibrosis via activating Nrf2-mediated anti-oxidant signaling pathway in spontaneous hypertensive rats,” Chinese Pharmacological Bulletin, vol. 34, no. 8, pp. 1073–1078, 2018. View at Publisher · View at Google Scholar
  • Xianglin Chu, Yiqing Wang, Liewen Pang, Jiechun Huang, Xiaotian Sun, and Xiaofeng Chen, “miR-130 aggravates acute myocardial infarction-induced myocardial injury by targeting PPAR-γ,” Journal of Cellular Biochemistry, 2018. View at Publisher · View at Google Scholar
  • Hanwen Chen, Hui Lin, Shujun Xie, Bo Huang, Yufeng Qian, Kelie Chen, Yuequn Niu, Han-Ming Shen, Jianting Cai, Peiwei Li, Jianhang Leng, Hao Yang, Dajing Xia, and Yihua Wu, “Myricetin inhibits NLRP3 inflammasome activation via reduction of ROS-dependent ubiquitination of ASC and promotion of ROS-independent NLRP3 ubiquitination,” Toxicology and Applied Pharmacology, 2018. View at Publisher · View at Google Scholar
  • Ran Li, Yuan Liu, Ying-guang Shan, Lu Gao, Fang Wang, and Chun-guang Qiu, “Bailcalin Protects against Diabetic Cardiomyopathy through Keap1/Nrf2/AMPK-Mediated Antioxidative and Lipid-Lowering Effects,” Oxidative Medicine and Cellular Longevity, vol. 2019, pp. 1–15, 2019. View at Publisher · View at Google Scholar
  • Lakshmikanthan Panneerselvam, Azhwar Raghunath, Kiruthika Sundarraj, and Ekambaram Perumal, “HO-1/HSP32 and Cardiac Stress Signaling,” Heat Shock Proteins in Signaling Pathways, vol. 17, pp. 139–159, 2019. View at Publisher · View at Google Scholar
  • Pei Nie, Fanjing Meng, Jinguo Zhang, Xiqing Wei, and Cheng Shen, “Astragaloside IV Exerts a Myocardial Protective Effect against Cardiac Hypertrophy in Rats, Partially via Activating the Nrf2/HO-1 Signaling Pathway,” Oxidative Medicine and Cellular Longevity, vol. 2019, pp. 1–16, 2019. View at Publisher · View at Google Scholar
  • Lan Bai, Xiaofang Li, Li He, Yu Zheng, Haiying Lu, Jinqi Li, Lei Zhong, Rongsheng Tong, Zhongliang Jiang, Jianyou Shi, and Jian Li, “Antidiabetic Potential of Flavonoids from Traditional Chinese Medicine: A Review,” The American Journal of Chinese Medicine, pp. 1–25, 2019. View at Publisher · View at Google Scholar
  • Zi-Jun Yang, Hong-Ru Wang, Yu-Iin Wang, Zi-Han Zhai, Liu-Wei Wang, Liang Li, Cheng Zhang, and Lin Tang, “Myricetin Attenuated Diabetes-Associated Kidney Injuries and Dysfunction via Regulating Nuclear Factor (Erythroid Derived 2)-Like 2 and Nuclear Factor-κB Signaling,” Frontiers in Pharmacology, vol. 10, 2019. View at Publisher · View at Google Scholar
  • Qiongfeng Wu, Kai Lu, Zhaoyang Zhao, Binbin Wang, Huixia Liu, Shaoshao Zhang, Jie Liao, Yu Zeng, Qian Dong, Ning Zhao, Bing Han, and Yimei Du, “Blockade of Transient Receptor Potential Vanilloid 4 Enhances Antioxidation after Myocardial Ischemia/Reperfusion,” Oxidative Medicine and Cellular Longevity, vol. 2019, pp. 1–17, 2019. View at Publisher · View at Google Scholar
  • Kaifeng Li, Mengen Zhai, Liqing Jiang, Fan Song, Bin Zhang, Jie Li, Hua Li, Buying Li, Lin Xia, Lu Xu, Yu Cao, Mengshan He, Hanzhao Zhu, Liyun Zhang, Hongliang Liang, Zhenxiao Jin, Weixun Duan, and Siwang Wang, “Tetrahydrocurcumin Ameliorates Diabetic Cardiomyopathy by Attenuating High Glucose-Induced Oxidative Stress and Fibrosis via Activating the SIRT1 Pathway,” Oxidative Medicine and Cellular Longevity, vol. 2019, pp. 1–15, 2019. View at Publisher · View at Google Scholar
  • Song Zhang, Xuehui Hu, Shun Guo, Lei Shi, Qing He, Ping Zhang, ShiQiang Yu, and Rong Zhao, “Myricetin ameliorated ischemia/reperfusion-induced brain endothelial permeability by improvement of eNOS uncoupling and activation eNOS/NO,” Journal of Pharmacological Sciences, 2019. View at Publisher · View at Google Scholar
  • Can Hu, Xin Zhang, Wenying Wei, Ning Zhang, Haiming Wu, Zhenguo Ma, Lingli Li, Wei Deng, and Qizhu Tang, “Matrine attenuates oxidative stress and cardiomyocyte apoptosis in doxorubicin-induced cardiotoxicity via maintaining AMPKα/UCP2 pathway,” Acta Pharmaceutica Sinica B, 2019. View at Publisher · View at Google Scholar
  • Sheng-lei Yan, Zhi-hong Wang, Mei-chin Mong, Ya-chen Yang, and Mei-chin Yin, “Combination of carnosine and asiatic acid provided greater anti-inflammatory protection for HUVE cells and diabetic mice than individual treatments of carnosine or asiatic acid alone,” Food and Chemical Toxicology, 2019. View at Publisher · View at Google Scholar
  • Hai-han Liao, Nan Zhang, Yan-yan Meng, Hong Feng, Jing-jing Yang, Wen-jin Li, Si Chen, Hai-ming Wu, Wei Deng, and Qi-zhu Tang, “Myricetin Alleviates Pathological Cardiac Hypertrophy via TRAF6/TAK1/MAPK and Nrf2 Signaling Pathway,” Oxidative Medicine and Cellular Longevity, vol. 2019, pp. 1–14, 2019. View at Publisher · View at Google Scholar
  • Li Deng, Xuxin Chen, Yi Zhong, Xing Wen, Ying Cai, Jiafu Li, Zhongcai Fan, and Jian Feng, “Activation of TGR5 Partially Alleviates High Glucose-Induced Cardiomyocyte Injury by Inhibition of Inflammatory Responses and Oxidative Stress,” Oxidative Medicine and Cellular Longevity, vol. 2019, pp. 1–11, 2019. View at Publisher · View at Google Scholar
  • Azadeh Aminzadeh, and Hamideh Bashiri, “Myricetin ameliorates high glucose‐induced endothelial dysfunction in human umbilical vein endothelial cells,” Cell Biochemistry and Function, 2019. View at Publisher · View at Google Scholar
  • Xiaozhou Ying, Xiaowei Chen, Te Wang, Wenhao Zheng, Long Chen, and Youjia Xu, “Possible osteoprotective effects of myricetin in STZ induced diabetic osteoporosis in rats,” European Journal of Pharmacology, pp. 172805, 2019. View at Publisher · View at Google Scholar
  • Xiangxiang Pan, Tingting Chen, Zengjie Zhang, Xiaowei Chen, Chengshu Chen, Long Chen, Xiangyang Wang, and Xiaozhou Ying, “Activation of Nrf2/HO-1 signal with Myricetin for attenuating ECM degradation in human chondrocytes and ameliorating the murine osteoarthritis,” International Immunopharmacology, vol. 75, pp. 105742, 2019. View at Publisher · View at Google Scholar
  • Amir M. Al Hroob, Mohammad H. Abukhalil, Omnia E. Hussein, and Ayman M. Mahmoud, “Pathophysiological mechanisms of diabetic cardiomyopathy and the therapeutic potential of epigallocatechin-3-gallate,” Biomedicine & Pharmacotherapy, vol. 109, pp. 2155–2172, 2019. View at Publisher · View at Google Scholar
  • Zhi-Dong Ge, Qingquan Lian, Xiaowen Mao, and Zhengyuan Xia, “Current Status and Challenges of NRF2 as a Potential Therapeutic Target for Diabetic Cardiomyopathy,” International Heart Journal, 2019. View at Publisher · View at Google Scholar