Myricetin Possesses Potential Protective Effects on Diabetic Cardiomyopathy through Inhibiting IκBα/NFκB and Enhancing Nrf2/HO-1
Myricetin promoted the production of Nrf2 downstream genes and inhibited the expression of 4-HEN in vivo. (a) Representative blots of heme oxygenase 1 (HO-1) and GAPDH (). (b) Histogram presented the calculation of Western blots of HO-1 (). (c), (d), and (e) The relative mRNA expression of NQO1, SOD1, and SOD2 (). (f) Representative blots showed the expression of 4-hydroxynonenal (4-HEN). (g) Histogram presented the calculation of Western blots of 4-HEN; all of the proteins and mRNA expression were normalized to GAPDH before relative quantitative analysis. Data were presented as means ± SEM. versus CON and # as compared with STZ group.