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Oxidative Medicine and Cellular Longevity
Volume 2017, Article ID 8370593, 14 pages
https://doi.org/10.1155/2017/8370593
Research Article

Myricetin Possesses Potential Protective Effects on Diabetic Cardiomyopathy through Inhibiting IκBα/NFκB and Enhancing Nrf2/HO-1

Hai-han Liao,1,2,3 Jin-xiu Zhu,1,2,3 Hong Feng,4 Jian Ni,1,2,3 Nan Zhang,1,2,3 Si Chen,2,3 Huang-jun Liu,1,2,3 Zheng Yang,1,2,3 Wei Deng,1,2,3 and Qi-Zhu Tang1,2,3

1Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China
2Cardiovascular Research Institute of Wuhan University, Wuhan, China
3Hubei Key Laboratory of Cardiology, Wuhan, China
4Department of Gerontology, Renmin Hospital of Wuhan University, Wuhan 430060, China

Correspondence should be addressed to Qi-Zhu Tang; nc.ude.uhw@gnatzq

Received 12 May 2017; Revised 18 July 2017; Accepted 26 July 2017; Published 24 September 2017

Academic Editor: Silvana Hrelia

Copyright © 2017 Hai-han Liao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Figure S1. Myricetin promoted the nuclei translocation of NF-κB as showed by immunofluorescence. Green represented the p-p65, blue represented the nuclei staining with DAPI, the merged pictures presented the location of NF-κB. Figure S2. Myricetin promoted the nuclei translocation of Nrf2 in mouse heart as showed by immunofluorescence. Green represented the cardiac troponin T (TnT), Red represented the Nrf2, blue represented the nuclei staining with DAPI, the merged pictures presented the location of Nrf. Figure S3. Myricetin inhibited cardiomyocytes apoptosis as showed by immunofluorescence. Green represented the TUNEL positive signaling, blue represented the nuclei staining with DAPI, the merged pictures presented cardiomyocytes apoptosis. Figure S4. Myricetin promoted the nuclei translocation of Nrf2 in NRCM as showed by immunofluorescence. Green represented the cardiac troponin T (TnT), Red represented the Nrf2, blue represented the nuclei staining with DAPI, the merged pictures presented the location of Nrf 2.

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