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Oxidative Medicine and Cellular Longevity
Volume 2017, Article ID 8494107, 10 pages
Research Article

Melatonin Supplementation Lowers Oxidative Stress and Regulates Adipokines in Obese Patients on a Calorie-Restricted Diet

1Chair of Medical Biology, Ludwik Rydygier Collegium Medicum of Nicolaus Copernicus University, 24 Karłowicza St, 85-092 Bydgoszcz, Poland
2The Tadeusz Browicz Provincial Hospital for Infectious Diseases and Observation, 12 św. Floriana St, 85-001 Bydgoszcz, Poland
3Department of Toxicology, Ludwik Rydygier Collegium Medicum of Nicolaus Copernicus University, 2 dr. A. Jurasza St, 85-089 Bydgoszcz, Poland

Correspondence should be addressed to Karolina Szewczyk-Golec;

Received 10 March 2017; Accepted 7 June 2017; Published 21 September 2017

Academic Editor: Giuseppe Cirillo

Copyright © 2017 Karolina Szewczyk-Golec et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Obesity is one of the major global health problems. Melatonin deficiency has been demonstrated to correlate with obesity. The aim of the study was to estimate the effect of melatonin on oxidative stress and adipokine levels in obese patients on a calorie-restricted diet. Thirty obese patients were supplemented with a daily dose of 10 mg of melatonin () or placebo () for 30 days with a calorie-restricted diet. Serum levels of melatonin, 4-hydroxynonenal (HNE), adiponectin, omentin-1, leptin, and resistin, as well as erythrocytic malondialdehyde (MDA) concentration and Zn/Cu-superoxide dismutase, catalase, and glutathione peroxidase (GPx) activities, were measured at baseline and after supplementation. Significant body weight reduction was observed only in the melatonin group. After melatonin supplementation, the adiponectin and omentin-1 levels and GPx activities statistically increased, whereas the MDA concentrations were reduced. In the placebo group, a significant rise in the HNE and a drop in the melatonin concentrations were found. The results show evidence of increased oxidative stress accompanying calorie restriction. Melatonin supplementation facilitated body weight reduction, improved the antioxidant defense, and regulated adipokine secretion. The findings strongly suggest that melatonin should be considered in obesity management. This trial is registered with CTRI/2017/07/009093.