Melatonin Supplementation Lowers Oxidative Stress and Regulates Adipokines in Obese Patients on a Calorie-Restricted Diet
Table 3
Effects of 30 days of melatonin (MEL; 10 mg/day) or placebo (PL) administration on the biochemical parameters in the obese subjects on calorie-restricted diet.
Parameter
MEL group ()
PL group ()
Baseline
After treatment
value
Baseline
After treatment
value
Serum
Melatonin (ng/L)
30.7 ± 6.37
33.7 ± 4.96
0.44
34.0 ± 2.55
25.0 ± 1.79
0.014
HNE (μg/L)
8.19 ± 1.36
8.48 ± 1.20
0.51
7.86 ± 0.68
18.4 ± 6.1
0.044
Adiponectin (mg/L)
2.82 ± 0.17
3.46 ± 0.18
0.029
3.17 ± 0.36
3.05 ± 0.56
0.70
Omentin-1 (μg/L)
380.1 ± 16.2
468.9 ± 16.7
0.0044
383.2 ± 20.8
396.4 ± 30.4
0.82
Leptin (μg/L)
33.1 ± 4.85
36.6 ± 5.76
0.70
36.9 ± 3.36
32.1 ± 6.86
0.58
Resistin (μg/L)
4.70 ± 0.42
4.45 ± 0.54
0.97
5.36 ± 0.41
5.16 ± 0.60
0.86
Erythrocyte
MDA (nmol/g Hb)
34.3 ± 2.44
24.5 ± 2.16
0.042
30.1 ± 2.89
27.4 ± 2.19
0.65
SOD-1 (IU/g Hb)
747.7 ± 19.4
762.0 ± 54.4
0.29
697.0 ± 16.7
687.9 ± 32.0
0.94
CAT (104 × IU/g Hb)
68.5 ± 2.94
64.7 ± 4.23
0.66
63.1 ± 2.89
65.0 ± 4.52
0.61
GPx (IU/g Hb)
5.49 ± 0.48
7.92 ± 0.56
0.0049
6.19 ± 0.58
7.19 ± 0.34
0.29
Each value is mean ± S.E.M. HNE: 4-hydroxynonenal; MDA: malondialdehyde; SOD-1: Zn/Cu-superoxide dismutase; CAT: catalase; GPx: glutathione peroxidase.
