Progression of Hepatic Adenoma to Carcinoma in Ogg1 Mutant Mice Induced by Phenobarbital

Table 1

Results of the histopathological analysis in Ogg1^−/− and Ogg1^+/+ mice.

	PB, 500 ppm		Control
Gender	Male	Female	Male	Female
Ogg1^−/−
Number of animals	20	20	20	20
Number of tumor-bearing mice (%)	5 (25)	12 (60)^a	3 (15%)	2 (10%)
Number of tumors/mouse	0.25	0.6^a	0.15	0.1
Ogg1^+/+
Number of animals	20	20	20	20
Number of tumor-bearing mice (%)	10 (50)	10 (50)	10 (50)	10 (50)
Number of tumors/mouse	0.5	0.5	0.5	0.5
Ogg1^−/−
M. lymphoma/leukemia	1 (5)	7 (35)^a,	0	0
Liver
HCA	0	0	0	0
HCC	2 (10)	2 (10)	0	0
Lung
Adenoma	1 (5)	2 (10)	3 (15)	2 (10)
Adenocarcinoma	2 (10)	0	0	0
Uterus
Endometrial adenoma	—	1 (5)	—	0
Tumor incidence (%)^b
Ogg1^+/+
M. lymphoma/leukemia	6 (30)	0	2 (10)	4 (20)
Liver
HCA	2 (10)	2 (10)	0	0
HCC	0	0	0	0
Lung
Adenoma	2 (10)	2 (10)	0	2 (10)
Adenocarcinoma	0	0	0	0
Uterus
Endometrial adenoma	—	2 (10)	—	0
Sarcoma	—	2 (10)	—	0
Renal
Adenocarcinoma	0	0	2 (10)	0
Pituitary gland
Adenoma	0	2 (10)	0	2 (10)
Zymbal gland
Adenoma	0	0	0	2 (10)
Subcutis
Fibrosarcoma	2 (10)	0/0	4 (20)	0
Pancreas
Adenoma	0	0	2 (10)	0
Ductal adenocarcinoma	0	2 (10)	0	0

^a versus the Ogg1^−/− control group; and versus the control or PB-treated Ogg1^+/+ group. ^bOnly organs with neoplastic lesions are listed.