Therapeutic Hypothermia Reduces Oxidative Damage and Alters Antioxidant Defenses after Cardiac Arrest

Figure 1

Biomarkers of oxidative damage and brain injury at 6, 12, 36, and 72 h after cardiac arrest (CA) in normothermic () versus hypothermic (n = 11) patients. In hypothermic patients, body temperature reached 33°C at 6 and 12 h and 36°C at 36 and 72 h after CA. (a) Carbonyl levels, a biomarker of oxidative damage to proteins; (b) malondialdehyde levels, a biomarker of oxidative damage to lipids; (c) S100B levels, a biomarker of brain injury; (d) xanthine oxidase (XO) activity, a biomarker of generation of superoxide free radical. Data are expressed as mean ± standard error, except for S100B levels, which are expressed as median and interquartile range. ^○Significantly different when comparing normothermic versus hypothermic groups at the same time point, . ^aSignificantly different within the group when compared to 6 h, . ^bSignificantly different within the group when compared to 12 h, .

(a) Protein carbonyl levels

(b) Malondialdehyde levels

(c) S100B levels

(d) Xanthine oxidase activity