Therapeutic Hypothermia Reduces Oxidative Damage and Alters Antioxidant Defenses after Cardiac Arrest

Table 1

Baseline characteristics of 42 comatose in- and out-of-hospital cardiac arrest patients.

	Normothermic ()	Hypothermic ()	All patients ()	value
Age—years (mean ± standard error)	62.6 ± 1.4	60.6 ± 1.6	62.5 ± 1.1	ns
Male patients—n (%)	20 (64.5)	7 (63.6)	27 (64.3)	ns
Time to ROSC—min (median ± min; max)	8 ± (2; 20)	6 ± (4; 16)	8 ± (2; 20)	ns
Survival—days (median ± min; max)	8 ± (1; 693)	16 ± (1; 163)	8 ± (1; 693)	ns
Presumed cause of arrest—number
Presumed cardiac origin	7/31	3/11	10/42
Presumed pulmonary origin	6/31	1/11	7/42
Presumed hemorrhagic origin	1/31	3/11	4/42
Presumed septic shock origin	5/31	4/11	9/42
Unspecified origin	12/31		12/42
Comorbidities—number
Acquired immunodeficiency syndrome	5/31	1/11	6/42
Acute biliary pancreatitis	1/31		1/42
Acute coronary syndrome		1/11	1/42
Acute renal failure		1/11	1/42
Acute respiratory infection	2/31		2/42
Acute respiratory failure		1/11	1/42
Anemia		1/11	1/42
Anorexia		1/11	1/42
Cancer	2/31	4/11	6/42
Chronic obstructive pulmonary disease	1/31		1/42
Cirrhosis		1/11	1/42
Cytomegalovirus	1/31		1/42
Chronic renal failure	4/31	1/11	5/42
Congestive heart failure	2/31		2/42
Diabetes mellitus	2/31	2/11	4/42
Enterorrhagia	1/31	3/11	4/42
Gastroenteritis	2/31	2/11	4/42
Hypertension	3/31		3/42
Hypothyroidism	1/31		1/42
Iron deficiency anemia	1/31		1/42
Ischemic heart disease	3/31	2/11	5/42
Meningoencephalitis	1/31		1/42
Myocardial infarction	4/31	1/11	5/42
Peripheral vascular disease	1/31		1/42
Pneumonia	2/31	1/11	3/42
Pulmonary embolism	2/31		2/42
Sepsis	6/31	4/11	10/42
Stroke	1/31	1/11	2/42
Tuberculosis	2/31	2/11	4/42
Ulcer	1/31	1/11	2/42

ROSC: return of spontaneous circulation; two patients in the normothermic group were alive 3 years after cardiac arrest.